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Jain, S. K.
- Phytochemical Analysis and Comparative Anticonvulsant Activity of Celastrus Paniculatus Willd. Mes Induced Seizure in Mice
Authors
1 Kunwar Haribansh Singh College of Pharmacy, Jaunpur (U.P.), IN
2 Institute of Pharmacy, Bundelkhand University, Jhansi (U.P.), IN
Source
Asian Journal of Research in Chemistry, Vol 5, No 1 (2012), Pagination: 83-86Abstract
The present study evaluated the anticonvulsant potential of petroleum ether and ethanolic extracts seeds of Celastrus paniculatus Willd. On Maximal electroshock and Pentylenetetrazole induce seizures in mice. The extract (petroleum ether and ethanolic) 200 mg/kg, 400 mg/kg, 600 mg /kg were given intraperitonially. The latency of seizures, death time and % mortality were observed. EECP and PECP gave significant protection against MES (Maximal electroshock) and PTZ (pentylenetetrazole) induced convulsion. The p value of PECP in PTZ P < 0.001and MES in PECP P < 0.01, P < 0.001. was statistically significant. Phytochemical Screening of the plant revels the presence of alkaloids, tannins, phenolic compound, fatty acids, steroids and flavonoids. The results indicate a possible efficacy potential of the plant extract of Celastrus paniculatus Willd. in convulsion.
Keywords
Celastrus paniculatus Willd, Phytochemical Convulsion, Maximal Electroshock, Mice.
- Synthesis, Characterization and Biological Evaluation of Novel 1,3,4-Oxadiazole Derivatives of 3-(2- napthoyl) Propionic Acid
Authors
1 Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, IN
2 Department of Pharmaceutical Sciences, GJUS and T, Hisar, Haryana, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 11 (2011), Pagination: 1755-1759Abstract
An easy access to a series of 1,3,4-oxadiazoles bearing a 1-(naphthalen-2-yl)propan-1-one side chain in the 4-position is described. These compounds were obtained starting from commercially available Naphthalene and aromatic acids. The work involves Friedal craft acylation reaction of hydrocarbons i.e. Naphthalene that result in formation of Aroyl propanoic acid and finally this Aroyl propanoic acid is condensed with different aromatic hydrazides and result in formation of 1,3,4 -oxadiazoles. The resulted compounds were screened for their biological activity.
Keywords
4-(Naphthalen-2-yl)-4-Oxobutanoic Acid, Aromatic Esters, Aromatic Hydrazides, Antiinflammatory Activity and Analgesic Activity.- Phytochemical Analysis and Comparative Anticonvulsant Activity of Celastrus Paniculatus Willd. Mes Induced Seizure in Mice
Authors
1 Kunwar Haribansh Singh College of Pharmacy, Jaunpur (U.P.), IN
2 Institute of Pharmacy, Bundelkhand University, Jhansi (U.P.), IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 10 (2011), Pagination: 1553-1556Abstract
The present study evaluated the anticonvulsant potential of petroleum ether and ethanolic extracts seeds of Celastrus paniculatus Willd. On Maximal electroshock and Pentylenetetrazole induce seizures in mice. The extract (petroleum ether and ethanolic) 200 mg/kg, 400 mg/kg, 600 mg /kg were given intraperitonially. The latency of seizures, death time and % mortality were observed. EECP and PECP gave significant protection against MES (Maximal electroshock) and PTZ (pentylenetetrazole) induced convulsion. The p value of PECP in PTZ P < 0.001and MES in PECP P < 0.01, P < 0.001. was statistically significant. Phytochemical Screening of the plant revels the presence of alkaloids, tannins, phenolic compound, fatty acids, steroids and flavonoids. The results indicate a possible efficacy potential of the plant extract of Celastrus paniculatus Willd. in convulsion.